256S-649266, a Novel Siderophore Cephalosporin: Mechanisms of enhanced activity and beta-lactamase stability
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چکیده
256. S-649266, a Novel Siderophore Cephalosporin: Mechanisms of enhanced activity and beta-lactamase stability Masakatsu Tsuji, PhD; Akinobu Ito, PhD; Tsukasa Horiyama; Norio Fukuhara, PhD; Rio Nakamura; Yoshionori Yamano, PhD; Jingoro Shimada, MD, PhD; Yoshikazu Ishii, PhD; Keizo Yamaguchi, MD, PhD; Kazuhiro Tateda, MD, PhD; Shionogi and Co., Ltd.: Osaka, Japan; Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan
منابع مشابه
252S-649266, a Novel Siderophore Cephalosporin: In vitro activity against Gram-negative bacteria
Background. S-649266 (’266) is a novel catechol-substituted siderophore cephalosporin for injection discovered by Shionogi and Co., Ltd. In this study, in vitro antibacterial activity of ’266 is evaluated against the clinical isolates of Gram-negative bacteria. Methods. MIC was measured by broth microdilution method according to Clinical and Laboratory Standard Institute except that CAMHB suppl...
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The stability to beta-lactamase hydrolysis of HR 756, a new cephalosporin antibiotic, was compared to the beta-lactamase stability of cefoxitin and cefuroxime. HR 756, cefoxitin, and cefuroxime were not hydrolyzed by Richmond type I, III, IV, and V beta-lactamases. Antibacterial activity of HR 756 correlated well with resistance to beta-lactamase hydrolysis except against Pseudomonas aeruginosa...
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Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii Cefider...
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The beta-lactamase stability and inhibitory activity of 1-oxa cephalosporin, (6R,7R)-7-[[carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, was investigated and compared to that of cefoxitin and cefotaxime. There was no detectable beta-lactamase hydrolysis of 1-oxa cephalosporin, cefotaxime and ...
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